Regional oligodendrocytopathy and astrocytopathy precede myelin loss and blood –brain barrier disruption in a murine model of osmotic demyelination syndrome

In conclusion, this murine model of ODS reproduces the CNS demyelination observed in human pathology and indicates ambiguous causes that is regional vulnerability of oligodendrocytes and astrocytes, while it discards BBB disruption as a primary cause of demyelination. This study also raises new queries about the glial heterogeneity in susceptible brain regions as well as about the early microglial activation associated with ODS.

Main Points

Rapid correction of chronic severe hyponatremia in mouse leads to functional impairments mimicking those found in ODS patients
In this model, necroptosis drives glial cell death in specific brain regions, precipitating myelin loss and blood–brain barrier disruption

Source: Glia - November 23, 2017 Category: Neurology Authors: Joanna Bouchat, Bruno Couturier, Catherine Marneffe, Fabrice Gankam ‐Kengne, Benoît Balau, Kathleen De Swert, Jean‐Pierre Brion, Luc Poncelet, Jacques Gilloteaux, Charles Nicaise Tags: RESEARCH ARTICLE Source Type: research