Radiotherapy-induced reactivation of neurotrophic human herpes viruses: overview and management

Infection by Human Herpes Viruses (HHV), types 1-3, are prevalent throughout the world [1,2]. It is known that cancer radiotherapy can reactivate HHV, but it is unclear how and to what extent reactivations can interact with or affect radiotherapeutic efficacy and patient outcomes (e.g., worsening of acute toxicities, inducing tumor radio-resistance). There are two in vitro studies, to date, that suggest an association between herpetic reactivation and radio-resistance [3,4].

Source: Journal of Clinical Virology - November 22, 2017 Category: Virology Authors: Marigdalia K. Ramirez-Fort, Jianying Zeng, Amir Feily, Luis A. Ramirez-Pacheco, Joseph M. Jenrette, David L. Mayhew, Talal Syed, S. Lewis Cooper, Craig Linden, Witney S. Graybill, Lars E. French, Christopher S. Lange Tags: Review Source Type: research