Modeling the structural origins of drug resistance to isoniazid via key mutations in Mycobacterium tuberculosis catalase-peroxidase, KatG

WHO reported 10.4 million new tuberculosis (TB) cases and 1.8 million deaths in 2015, making M. tuberculosis the most successful human pathogen with highest mortality among infectious diseases [1],[2]. Drug-resistant TB is a major threat to global TB control [2,3]. Recently Torres et al. [4] identified 14 novel substitutions in M. tuberculosis-KatG (the enzyme associated with resistance to isoniazid —an important first-line anti-TB drug) and demonstrated that 12 of the 14 can cause INH-resistance in M.
Source: Tuberculosis - Category: Respiratory Medicine Authors: Tags: Molecular Aspects Source Type: research