Altered resting state functional connectivity in early course schizophrenia

We examined functional connectivity in a clinically homogenous sample of 34 early course schizophrenia patients compared and 19 healthy controls using resting state functional magnetic resonance imaging (rsfMRI).Mean duration of illness for schizophrenia patients was 4 ±1.78 years. Following a comprehensive clinical assessment, rsfMRI data were acquired using a 3.0 T magnetic resonance imaging scanner, and analyzed using FSL version 5.01 software (FMRIB's Software Library, www.fmrib.ox.ac.uk/fsl).Compared to healthy controls, schizophrenia patients had significan tly decreased functional connectivity in the left fronto-parietal network, lateral and medial visual network, motor network, default mode network and auditory network.
Source: Psychiatry Research: Neuroimaging - Category: Psychiatry Authors: Source Type: research