A new therapeutic proposal for inoperable osteosarcoma: Photodynamic therapy

Balb/c nude mice were transplanted with osteosarcoma tumor cells. When the tumor volume exceeded 100mm3, which was confirmed by Nuclear Medicine imaging after 99mTc-MIBI injection, mice were administered with the photosensitizer (5,15-bis(2-bromo-5-hydroxyphenyl)porphyrin). Photodynamic therapy was completed 72h later using light irradiation. PDT leads to a necrosis decreasing tumor growth. Osteosarcoma models in athymic mice are feasible and facilitate simple in vivo monitoring for the development of new therapies.

Source: Photodiagnosis and Photodynamic Therapy - November 21, 2017 Category: Laser Surgery Authors: Guilherme Chohfi de Miguel, Ana Margarida Abrantes, Mafalda Laranjo, Ana Yoshie Kitagawa Grizotto, Bruno Camporeze, Jos é Aires Pereira, Gonçalo Brites, Arménio Serra, Marta Pineiro, António Rocha-Gonsalves, Maria Filomena Botelho, Denise Gonçalves P Source Type: research