The IL ‐21‐mTOR axis blocks treg differentiation and function by suppression of autophagy in patients with systemic lupus erythematosus
ConclusionsIL‐21‐driven mTOR activation is a pharmacologically targetable checkpoint of deficient autophagy that underlies Treg dysfunction in SLE.This article is protected by copyright. All rights reserved.
Source: Arthritis and Rheumatism - Category: Rheumatology Authors: Hiroshi Kato, Andras Perl Tags: Full Length Source Type: research