Transit time mapping in the mouse brain using time ‐encoded pCASL

In conclusion, this study shows the successful implementation of te‐pCASL in mice, making it possible, for the first time, to measure ATT in mice in a time‐efficient manner. With time‐encoded pseudo‐continuous arterial spin labeling (te‐pCASL), time‐efficient multi‐delay sampling can be performed to estimate the arrival of the arterial spin labeling (ASL) signal in the brain. In this study, we show the successful implementation of a Hadamard‐12‐encoded pCASL sequence in mice, yielding perfusion‐weighted images at 11 time points (a). By fitting a perfusion model to the ASL signal time course (b), the arterial transit time (ATT) and cerebral blood flow (CBF) can be estimated and mapped (c).

http://onlinelibrary.wiley.com/resolve/doi?DOI=10.1002%2Fnbm.3855

Source: NMR in Biomedicine - November 21, 2017 Category: Radiology Authors: Lydiane Hirschler, Leon P. Munting, Artem Khmelinskii, Wouter M. Teeuwisse, Ernst Suidgeest, Jan M. Warnking, Louise Weerd, Emmanuel L. Barbier, Matthias J.P. Osch Tags: RESEARCH ARTICLE Source Type: research