Localized Optogenetic Targeting of Rotors in Atrial Cardiomyocyte Monolayers [Original Articles]

Conclusions:
Localized optogenetic targeting of rotors in atrial monolayers could lead to both stabilization and destabilization of reentrant activity. For termination, however, a line of block is required reaching from the core region to at least 1 unexcitable boundary. These findings may improve our understanding of the mechanisms involved in rotor-guided ablation.

Source: Circulation: Arrhythmia and Electrophysiology - November 2, 2017 Category: Cardiology Authors: Feola, I., Volkers, L., Majumder, R., Teplenin, A., Schalij, M. J., Panfilov, A. V., de Vries, A. A. F., Pijnappels, D. A. Tags: Catheter Ablation and Implantable Cardioverter-Defibrillator, Atrial Fibrillation, Basic Science Research, Gene Therapy, Mechanisms Original Articles Source Type: research