The COMT Val158Met Polymorphism and Exploratory Behavior in Bipolar Mania

Conclusion: This preliminary study suggests that arousal and positive valence are influenced in a linear fashion by COMT, presumably due to increased catecholamine in frontal regions, but these findings require replication in a larger sample. The hBPM can enable cross-species and transdiagnostic studies to inform neurobiology of psychiatric disorders.Mol Neuropsychiatry 2017;3:151-156
Source: Molecular Neuropsychiatry - Category: Neuroscience Source Type: research