Design and study of lipopeptide inhibitors on preventing aggregation of human islet amyloid polypeptide residues 11 ‐20

This study demonstrated the efficiency of lipopeptides in inhibiting the aggregation of hIAPP11‐20 and proved that MST could be regarded as an appropriate and rapid method to screen potential inhibitors of hIAPP11‐20 or other amyloid proteins. This study also broadens the types of inhibitors on inhibiting amyloid formation of hIAPP. A shows relative fluorescence of hIAPP11‐20 incubated with different lipopeptides and B shows the affinity between FITC‐labeled hIAPP11‐20 and C14R4 (the most potential inhibitor) by microscale thermophoresis.
Source: Journal of Peptide Science - Category: Biochemistry Authors: Tags: RESEARCH ARTICLE Source Type: research