Brain signature of mild stages of cognitive and behavioral impairment in amyotrophic lateral sclerosis

We aimed to assess the brain signature of cognitive and behavioral impairment in C9orf72-negative non-demented ALS patients. The study included 50 amyotrophic lateral sclerosis (ALS) patients; of the 75 initially recruited, and 38 healthy controls.. High-resolution T1-weighted and spin-echo diffusion tensor images were acquired in a 3T MRI scanner. The multi atlas-based analysis protocol and the FreeSurfer tool were employed for grey matter assessment, and fiber tractography for white matter evaluation.

Source: Psychiatry Research: Neuroimaging - November 20, 2017 Category: Psychiatry Authors: Lucas M T Branco, Thiago J R de Rezende, Caroline de O. Roversi, Tamires Zanao, Raphael F Casseb, Brunno M de Campos, Marcondes C Fran ça Source Type: research