Dopamine in high-risk populations: a comparison of subjects with 22q11.2 deletion syndrome and subjects at ultra high-risk for psychosis

Striatal dopamine (DA) dysfunction has been consistently reported in psychotic disorders. Differences and similarities in the pathogenesis between populations at clinical and genetic risk for developing psychosis are yet to be established. Here we explored markers of dopamine (DA) function in subjects meeting clinically ultra-high risk criteria for psychosis (UHR) and in subjects with 22q11.2 deletion syndrome (22q11DS), a genetic condition associated with significant risk for developing psychotic disorders.

Source: Psychiatry Research: Neuroimaging - November 20, 2017 Category: Psychiatry Authors: Claudia Vingerhoets, Oswald J.N. Bloemen, Erik Boot, Geor Bakker, Mariken B. de Koning, Fabiana da Silva Alves, Jan Booij, Th érèse A.M.J. van Amelsvoort Source Type: research