The DNA methylation status of genes encoding Matrix metalloproteinases and Tissue inhibitors of Matrix metalloproteinases in endometriosis

This study evaluated the regulation of abnormal MMP and TIMP gene expression during endometriosis. Among the two genes families, promoter regions of MMP2, MMP3, MMP7, TIMP3, and TIMP4 were significantly altered in proliferative‐phase endometriotic lesions compared to menstrual cycle‐matched eutopic tissue from endometriosis‐free women. In addition, a negative correlation was found between the DNA methylation status of the promoter region and transcript abundance of MMP2. Our findings suggest that changes in DNA methylation at the promoter region of MMP2 could underlie the changes in its expression in the ectopic endometria from patients with endometriosis. This article is protected by copyright. All rights reserved
Source: Molecular Reproduction and Development - Category: Reproduction Medicine Authors: Tags: RESEARCH ARTICLE Source Type: research