Regulation of genome organization and gene expression by nuclear mechanotransduction

Nature Reviews Molecular Cell Biology 18, 717 (2017).
doi:10.1038/nrm.2017.101

Authors: Caroline Uhler & G. V. Shivashankar
It is well established that cells sense chemical signals from their local microenvironment and transduce them to the nucleus to regulate gene expression programmes. Although a number of experiments have shown that mechanical cues can also modulate gene expression, the underlying mechanisms are far from

Source: Nature Reviews Molecular Cell Biology - October 18, 2017 Category: Cytology Authors: Caroline Uhler G. V. Shivashankar Tags: Review Source Type: research