Liver injury induced by clomiphene citrate: A case report and literature reviews

We report a case of liver injury which is associated with administration of clomiphene citrate in a male patient. Case summaryA 31‐year‐old man who was treated by clomiphene citrate for 5 days was transferred to our emergency room with reddish‐brown urine and upper abdominal pain. The levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were elevated. Based on the subsequent examination, he was diagnosed with liver injury and cholecystitis. The levels of AST and ALT returned to normal range after discontinuation of clomiphene citrate and symptomatic treatment. What is new and conclusionThe mechanism of liver injury caused by clomiphene citrate is still unclear. Polymorphism of CYP2D6 may have had an effect. Liver function tests should be performed when there is upper abdominal pain after administration of clomiphene citrate. A case of liver injury induced by clomiphene citrate in a male patient was reported which may caused by polymorphism of CYP2D6. Liver function tests should be performed after adminitration of clomiphene citrate.
Source: Journal of Clinical Pharmacy and Therapeutics - Category: Drugs & Pharmacology Authors: Tags: CASE REPORT Source Type: research