Pituitary pars intermedia dysfunction does not necessarily impair insulin sensitivity in old horses.

The objective of the study was to determine if aged horses with PPID had reduced insulin sensitivity and alterations in the insulin-mediated signaling pathways in the skeletal muscle when compared to healthy aged horses. Isoglycemic hyperinsulinemic clamp procedures were conducted in twelve horses that were classified as either PPID (n=6; age 25.0 ± 2.5 yr; mean ± SD) or non-PPID, aged-matched controls (Control) (n = 6; age: 25.7 ± 2.0 yr).

Source: Domestic Animal Endocrinology - August 1, 2014 Category: Endocrinology Authors: L.M. Mastro, A.A. Adams, K.L. Urschel Source Type: research