89Zr for antibody labeling and in vivo studies – a comparison between liquid and solid target production

Zirconium-89 (89Zr, t1/2 = 78.4 h) liquid target (LT) production offers an approach to introduce this positron-emitting isotope to cyclotron centres without the need for a separate solid target (ST) production set up. We compared the production, purification, and antibody radiolabeling yields of 89Zr-(LT) and 89Zr-(ST), and assessed the feasibility of 89Zr-(LT) for preclinical PET/CT.

Source: Nuclear Medicine and Biology - November 16, 2017 Category: Nuclear Medicine Authors: Gemma M. Dias, Caterina F. Ramogida, Julie Rousseau, Nicholas A. Zacchia, Cornelia Hoehr, Paul Schaffer, Kuo-Shyan Lin, Fran çois Bénard Source Type: research