2 ‐Alkylsulfanyl‐4(5)‐aryl‐5(4)‐heteroarylimidazoles: An Overview on Synthetic Strategies and Biological Activity

2‐Alkylsulfanyl‐4(5)‐aryl‐5(4)‐heteroarylimidazoles represent an important class of ATP‐competitive protein kinase inhibitors, offering the possibility of multiple interactions with different regions of the target enzyme. The necessity of exploring the effects of diverse chemical decorations around the imidazole core prompted the design of several synthetic routes aimed at achieving both efficiency and flexibility. Additionally, the optimization of established protocols and the extensive use of transition metal‐catalyzed cross‐coupling reactions have been broadening the spectrum of preparative methodologies within the last decade. This review summarizes the progress in the development of synthetic strategies leading to 2‐alkylsulfanyl‐4(5)‐aryl‐5(4)‐heteroarylimidazoles and 1‐alkyl‐2‐alkylsulfanyl‐4(5)‐aryl‐5(4)‐heteroarylimidazoles and offers a glance at the biological activities of this class of compounds. Many examples of 2‐alkylsulfanyl‐4(5)‐aryl‐5(4)‐heteroarylimidazoles and 1‐alkyl‐2‐alkylsulfanyl‐4(5)‐aryl‐5(4)‐heteroarylimidazoles have been reported as ATP‐competitive inhibitors of different protein kinases. This review focuses on how diverse synthetic strategies offer high flexibility in varying the substitution pattern of this class of molecules, providing the optimal moieties for potent and selective inhibition of the desired target enzyme.
Source: Archiv der Pharmazie - Category: Drugs & Pharmacology Authors: Tags: Review Article Source Type: research