Changes in platelet Bax levels contribute to impaired platelet response to thrombin after cardiopulmonary bypass: prospective observational clinical and laboratory investigations

Conclusions. CPB increases platelet Bax expression, which contributes to reduced platelet-surface GPIb expression and thrombin-induced platelet calcium changes. These changes in platelet apoptotic signalling might contribute to platelet dysfunction after CPB.Clinical trial registration. UMIN Clinical Trials Registry (number UMIN000006033).
Source: British Journal of Anaesthesia - Category: Anesthesiology Source Type: research