Limitations of clinical studies evaluating tertiary hyperalgesia

Editor —Shin and colleagues1 suggested that magnesium sulphate attenuates increased pain intensity at sites remote from the surgical site (tertiary hyperalgesia), based on the observation of reduced pain in a magnesium-administered groupvs controls after a second total knee arthroplasty (TKA) during staged bilateral total knee arthroplasty. This may serve as a basis for further studies of tertiary hyperalgesia, a topic that has not been studied extensively to date. Potential confounding factors or possible misinterpretations associated with this study should be discussed to enhance its influence on future studies.
Source: British Journal of Anaesthesia - Category: Anesthesiology Source Type: research