Development of a non-human primate BCG infection model for the evaluation of candidate tuberculosis vaccines

The lack of validated immunological correlates of protection makes tuberculosis vaccine development difficult and expensive. Using intradermal bacille Calmette-Gur éin (BCG) as a surrogate for aerosol Mycobacterium tuberculosis (M.tb) in a controlled human infection model could facilitate vaccine development, but such a model requires preclinical validation. Non-human primates (NHPs) may provide the best model in which to do this. Cynomolgus and rhesus macaqu es were infected with BCG by intradermal injection.

Source: Tuberculosis - November 15, 2017 Category: Respiratory Medicine Authors: Stephanie A. Harris, Andrew White, Lisa Stockdale, Rachel Tanner, Laura Sibley, Charlotte Sarfas, Joel Meyer, Jonathan Peter, Matthew K. O'Shea, Zita-Rose Manjaly Thomas, Ali Hamidi, Iman Satti, Mike J. Dennis, Helen McShane, Sally Sharpe Tags: Model Systems Source Type: research