Evaluation of dynamic contrast-enhanced MRI biomarkers for stratified cancer medicine: How do permeability and perfusion vary between human tumours?

Solid tumours exhibit enhanced vessel permeability and fenestrated endothelium to varying degree, but it is unknown how this varies in patients between and within tumour types. Dynamic contrast-enhanced (DCE) MRI provides a measure of perfusion and permeability, the transfer constant Ktrans, which could be employed for such comparisons in patients.

Source: Magnetic Resonance Imaging - November 14, 2017 Category: Radiology Authors: Ross A. Little, Herv é Barjat, Jennifer I. Hare, Mary Jenner, Yvonne Watson, Susan Cheung, Katherine Holliday, Weijuan Zhang, James P.B. O'Connor, Simon T. Barry, Sanyogitta Puri, Geoffrey J.M. Parker, John C. Waterton Tags: Original contribution Source Type: research