[Correspondence] Chelated or dechelated gadolinium deposition – Authors' reply

We thank Alexander Radbruch and colleagues for their comments regarding our and more recent publications. They highlight an experiment comparing gadolinium retention in the rat brain after high doses of linear or macrocyclic gadolinium-based contrast agents (GBCAs),1 demonstrating retention of tiny amounts of soluble gadolinium in brain tissue for all agents, but higher concentrations of the insoluble fraction for linear than for macrocyclic agents. Of note, another paper2 by the same group reported that brain tissue of rats with proven gadolinium deposition showed no histopathological changes with either linear or macrocyclic agents.

Source: Lancet Neurology - November 15, 2017 Category: Neurology Authors: Vikas Gulani, Fernando Calamante, Frank G Shellock, Emanuel Kanal, Scott B Reeder, International Society for Magnetic Resonance in Medicine Tags: Correspondence Source Type: research