[Comment] Neurodegeneration in histiocytoses might start in utero
Histiocytic disorders, such as Langerhans cell histiocytosis and Erdheim-Chester disease, are characterised by inflammation and accumulation of cells derived from the monocyte and macrophage lineages, resulting in tissue damage.1 Neurodegenerative lesions in Langerhans cell histiocytosis are a devastating type of CNS involvement —different from tumour infiltration—in which patients present with progressive symmetric cerebellar syndrome, tetrapyramidal syndrome with or without motor deficits, pseudobulbar palsy, or cognitive impairment.
Source: Lancet Neurology - Category: Neurology Authors: Julien Haroche, Fleur Cohen-Aubart, Jean-Fran çois Emile, Jean Donadieu, Zahir Amoura Tags: Comment Source Type: research