Reward and loss anticipation in panic disorder: An FMRI study

Patients with panic disorder (PD) are overly sensitive to unpredictably aversive events (Grillon et al., 2008) and have a strong fear of losing control (Starcevic et al., 1993). They have stronger concerns during anticipation of potential problems than control participants (Wiborg et al., 2005). They also show higher activation to panic-pictures in regions involved in interoceptive processing (Engel et al., 2016), pointing to a dysfunctional regulation of negative emotionality. Correspondingly, PD patients display elevated scores on the harm avoidance temperament scale (Ampollini et al., 1997; Izci et al., 2014; Kennedy et al., 2001; Marchesi et al., 2006; Wachleski et al., 2008; Wiborg et al., 2005).

Source: Psychiatry Research: Neuroimaging - November 14, 2017 Category: Psychiatry Authors: Dada Held, Philipp Sterzer, Florian Schlagenhauf, Corinna Pehrs, Andre Wittmann, Meline Stoy, Claudia H ägele, Brian Knutson, Andreas Heinz, Andreas Ströhle Source Type: research