Retromer and the CIMPR – time for a trial separation?

The retromer cargo‐selective complex (CSC) comprising Vps35, Vps29 and Vps26 mediates the endosome‐to‐Golgi retrieval of the cation‐independent mannose 6‐phosphate receptor (CIMPR). Or does it? Recently published data has questioned the validity of this long established theory. Here the evidence for and against a role for the retromer CSC in CIMPR endosome‐to‐Golgi retrieval is examined in the light of the new data that the SNX‐BAR dimer is actually responsible for CIMPR retrieval.

Synopsis
The cation‐independent mannose 6‐phosphate receptor (CIMPR) has long been regarded as the archetypal cargo protein for the retromer complex and its retrieval to the Golgi was thought to be mediated by the cargo‐selective complex (CSC). But new data showing that the SNX‐BAR dimer associates with the CIMPR has questioned this view. Here I discuss the recent findings in the context of several years of published data on retromer and propose a new model for retromer‐mediated CIMPR retrieval.

Source: Traffic - November 14, 2017 Category: Research Authors: Matthew N.J. Seaman Tags: PERSPECTIVE Source Type: research