Randomized study of IV prochlorperazine plus diphenhydramine vs IV hydromorphone for migraine

Conclusions:
IV hydromorphone is substantially less effective than IV prochlorperazine for the treatment of acute migraine in the ED and should not be used as first-line therapy.

ClinicalTrials.gov identifier:
NCT02389829.

Classification of evidence:
This study provides Class I evidence that for patients in the ED with migraine, IV prochlorperazine + diphenhydramine is superior to IV hydromorphone.

Source: Neurology - November 13, 2017 Category: Neurology Authors: Friedman, B. W., Irizarry, E., Solorzano, C., Latev, A., Rosa, K., Zias, E., Vinson, D. R., Bijur, P. E., Gallagher, E. J. Tags: Migraine, Clinical trials Randomized controlled (CONSORT agreement), Class I ARTICLE Source Type: research