Reduced frontal grey matter, life history of aggression, and underlying genetic influence

Physically healthy, adult, same-sexed twins (n = 287) from a population-based twin cohort underwent high-resolution magnetic resonance imaging (MRI) to identify fronto-limbic brain regions significantly associated with lifetime history of aggression. MRI scans used a 3D magnetization-prepared rapid acquisition gradient-echo (MP-RAGE) sequence, for voxel-based morphometry (VBM) and history of aggressive behavior was assessed using the Life History of Aggression measure. Aggression had modest, inverse associations with grey matter volume (GMV) in medial prefrontal cortex (mPFC, b = −0.20, se = 0.05, p

Source: Psychiatry Research: Neuroimaging - November 13, 2017 Category: Psychiatry Authors: Emil F. Coccaro, Henk Cremers, Jennifer Fanning, Eryka Nosal, Royce Lee, Sarah Keedy, Kristen C. Jacobson Source Type: research