Pro- and anti-inflammatory mediators change leukotriene B and leukotriene C synthesis and secretion in an inflamed porcine endometrium

We studied the effect of lipopolysaccharide (LPS), proinflammatory cytokines (tumor necrosis factor α [TNF-α] and interleukin [IL] 1β), and anti-inflammatory cytokines (IL-4 and IL-10) on leukotriene (LT) A4 hydrolase and LTC4 synthase (LTCS) protein expression in, and LTB4 and LTC4 secretion from, an inflamed porcine endometrium. On day 3 of the estrous cycle (day 0 of the study), 50 mL of either saline or Escherichia coli suspension (109 CFU/mL) was injected into each uterine horn of gilts (n = 12 per group).
Source: Domestic Animal Endocrinology - Category: Endocrinology Authors: Source Type: research