Vascular endothelial growth factor a improves quality of matured porcine oocytes and developing parthenotes

The objective was to determine effects of exogenous recombinant human VEGFA (or VEGFA165) in culture media on porcine oocyte maturation and parthenote development. Adding 5 ng/mL VEGFA to the culture medium improved the maturation rate of denuded oocytes (P < 0.05), although 5, 50, or 500 ng/mL did not significantly affect nuclear maturation of oocytes. Parthenotes from oocytes cultured either in in vitro maturation or in vitro culture medium supplemented with 5 or 50 ng/mL VEGFA had an improved blastocyst rate and increased total numbers of cells (P < 0.05).

Source: Domestic Animal Endocrinology - June 25, 2014 Category: Endocrinology Authors: M. Kere, C. Siriboon, J.W. Liao, N.W. Lo, H.I. Chiang, Y.K. Fan, J.P. Kastelic, J.C. Ju Source Type: research