SNAI1 functional variant associated with decreased risk for lung cancer

This article adds another layer of complexity and I post it (rather belatedly) now because I find in it such an intriguing finding that a variant protein could have functional consequences that are observable as a clinical outcome with regard to COPD and NSCLC.  Moreover, this variant was discovered to attenuate Snai1’s ability to specifically up-regulate mesenchymal biomarkers (i.e., fibronectin and vimentin) expression, and to promote EMT-like changes, including morphologic changes, cell migration, and invasion.

Source: The Daily Sign-Out - June 26, 2014 Category: Pathologists Authors: Mark D. Pool, M.D. Tags: Cancer Biology Epithelial-to-Mesenchymal Transition Lung Cancer Non small cell lung cancer Source Type: blogs