IL-17 and related cytokines involved in the pathology and immunotherapy of ultiple Sclerosis: current and future developments

Multiple sclerosis (MS), an autoimmune neurological disorder, is driven by self-reactive T helper (Th) cells. Research on the role of Th17 lymphocytes in MS pathogenesis has made significant progress in identifying various immunological as well as environmental factors that induce the differentiation and expansion of these cells, different subsets of Th17 cells with varying degrees of pathogenicity, and the role of the secreted effector cytokines. While approved therapies for MS offer significant benefit to patients, there remain unmet needs.

Source: Cytokine and Growth Factor Reviews - July 28, 2014 Category: Molecular Biology Authors: Dirk W. Luchtman, Erik Ellwardt, Catherine Larochelle, Frauke Zipp Source Type: research