The effects of Icariin on wound healing of extraction sites with administration of Zoledronic and Dexamethasone: A rat model study

ConclusionConcurrent use of Zoledronic and Dexamethasone inhibits expression of VEGF, OCN and wound healing; and increases the number of osteoclast cells, serum CTX‐1 and TRACP‐5b after discontinuation for ten weeks. Icariin weakens those effects at a dose‐dependent manner but does not influence onset of BRONJ.This article is protected by copyright. All rights reserved.

Source: Journal of Oral Pathology and Medicine - November 1, 2017 Category: Pathology Authors: Jie Liu, Nikos Mattheos, Cheng Su, Chuanxi Deng, Nanyu Luo, Zekun Wang, Hua Tang Tags: Original Article Source Type: research