The Prodigious Network of Chromosome 17 miRNAs Regulating Cancer Genes that Influence the Hallmarks of Cancer

Chromosome 17 (Chr17) harbors crucial genes that encode proteins implicated in a variety of cancers including some that guard cancer cells from genomic instability and others that interfere with metastasis. Included amongst the genes on chr17 that regulate biological processes fundamental to the genesis of cancer are TP53, BRCA1, CCL5, NF-1, and GRB7. As many as 50% of all human tumors and at least 30% of breast carcinomas contain p53 mutations, while 30-40% of breast cancers have defective BRCA1.
Source: Seminars in Oncology - Category: Cancer & Oncology Authors: Source Type: research