In vitro activity of tedizolid against the Mycobacterium abscessus complex

Infections due to Mycobacterium abscessus carry a poor prognosis since this rapidly growing mycobacterium is intrinsically resistant to most antibiotics. Here, we evaluate the in vitro activity of the new oxazolidinone tedizolid against a collection of 44M. abscessus clinical isolates. The MIC50s and MIC90s of tedizolid (2 and 8 μg/mL, respectively) were 2- to 16-fold lower than those of linezolid. There was no difference between the three M. abscessus subspecies. Time-kill assays did not show any bactericidal activity at 4- and 8-fold the MIC.
Source: Diagnostic Microbiology and Infectious Disease - Category: Microbiology Authors: Source Type: research