Imbalance of Caveolin‐1 and eNOS Expression in the Pulmonary Vasculature of Experimental Diaphragmatic Hernia

ConclusionThe striking evidence of markedly decreased gene and protein expression of Cav‐1 with concurrently increased eNOS gene and protein expression in the pulmonary vasculature suggests that activation of eNOS secondary to Cav‐1 deficiency may play an important role in the pathogenesis of PH in the nitrofen‐induced CDH

Source: Birth Defects Research Part B: Developmental and Reproductive Toxicology - June 1, 2014 Category: Perinatology & Neonatology Authors: Alejandro Hofmann, Jan‐Hendrik Gosemann, Toshiaki Takahashi, Florian Friedmacher, Johannes W. Duess, Prem Puri Tags: Research Article Source Type: research