Versatile Alkylation of (Hetero)Aryl Iodides with Ketones via β-C(sp3)–H Activation

We report Pd(II)-catalyzed β-C(sp3) –H (hetero)arylation of a variety of ketones using a commercially available 2,2-dimethyl aminooxyacetic acid auxiliary. Facile installation and removal of the auxiliary as well as its superior scope for both ketones and (hetero)aryl iodides overcome the significant limitations of the previous ly reported β-C(sp3) –H arylation of ketones.

Source: Organometallic Current - November 9, 2017 Category: Chemistry Tags: Alkylation Pd Catalyzed sp3 C-H Activation Source Type: blogs