Chemoselective Intermolecular Cross-Enolate-Type Coupling of Amides

JacsChemoselective Intermolecular Cross-Enolate-Type Coupling of Amides: A new approach for the synthesis of 1,4-dicarbonyl compounds is reported. Chemoselective activation of amide carbonyl functionality and subsequent umpolungviaN-oxide addition generates an electrophilic enolonium species that can be coupled with a wide range of nucleophilic enolates.

Source: Organometallic Current - November 9, 2017 Category: Chemistry Tags: Chemoselective Cross Coupling Source Type: blogs