Effects of dopamine receptor antagonist antipsychotic therapy on blood pressure

ConclusionBased upon this review, individuals on antipsychotic agents, particularly clozapine, should be routinely monitored for hypertension, and addition of antihypertensive agents such as angiotensin‐converting enzyme (ACE) inhibitors or angiotensin receptor blockers (ARBs) is indicated if hypertension occurs. Dopamine receptors play a role in blood pressure regulation. The objective of this review is to investigate the association between dopamine antagonist use and hypertension. Based upon this review, individuals on antipsychotic agents, particularly clozapine, should have blood pressure routinely monitored, and addition of antihypertensive agents such as angiotensin‐converting enzyme (ACE) inhibitors or angiotensin receptor blockers (ARBs) may be indicated.
Source: Journal of Clinical Pharmacy and Therapeutics - Category: Drugs & Pharmacology Authors: Tags: REVIEW ARTICLE Source Type: research