Toxoplasma gondii infection shifts dendritic cells into an amoeboid rapid migration mode encompassing podosome dissolution, secretion of TIMP ‐1 and reduced proteolysis of extracellular matrix

We report that increased TIMP‐1 secretion and cytoskeletal rearrangements encompassing podosome dissolution are features of Toxoplasma‐induced hypermigration of DCs with an impact on matrix degradation. Jointly, the data highlight how an obligate intracellular parasite orchestrates key regulatory cellular processes consistent with non‐proteolytic amoeboid migration of the vehicle cells that facilitate its dissemination.
Source: Cellular Microbiology - Category: Microbiology Authors: Tags: RESEARCH ARTICLE Source Type: research