Monogenic interferonopathies: Phenotypic and genotypic findings of CANDLE syndrome and its overlap with C1q deficient SLE.

ConclusionThis is the first report of CANDLE syndrome in an Arab population; our patients had heterogeneous phenotypic and genetic features with overlap manifestations with C1q deficient SLE. Both are monogenic interferonopathies. However, C1q deficient SLE had more systemic inflammatory disease.

Source: APLAR Journal of Rheumatology - November 8, 2017 Category: Rheumatology Authors: Sulaiman M. Al ‐Mayouf, Alhanouf AlSaleem, Nora AlMutairi, Abdullah AlSonbul, Tariq Alzaid, Anas M. Alazami, Hamoud Al‐Mousa Tags: Original Article Source Type: research