Neuropeptide Y Y2 antagonist treated ovariectomized mice exhibit greater bone mineral density

In this study, ovariectomized (OVX) mice were injected once daily with JNJ-31020028, a brain penetrant Y2 receptor small molecule antagonist to determine the effects on bone formation. Antagonist treated mice had reduced weight and showed increased whole-body bone mineral density compared to vehicle-injected mice.

Source: Neuropeptides - November 7, 2017 Category: Neuroscience Authors: K.L. Seldeen, P.G. Halley, C.H. Volmar, M.A. Rodr íguez, M. Hernandez, M. Pang, S.K. Carlsson, L.J. Suva, C. Wahlestedt, B.R. Troen, S.P. Brothers Source Type: research