Human Interactomics: Comparative Analysis of Different Protein Interaction Resources and Construction of a Cancer Protein –Drug Bipartite Network

Publication date: Available online 6 November 2017 Source:Advances in Protein Chemistry and Structural Biology Author(s): Javier De Las Rivas, Diego Alonso-López, Mónica M. Arroyo Unraveling the protein interaction wiring that occurs in human cells as a scaffold of biological processes requires the identification of all elements that constitute such molecular interaction networks. Proteome-wide experimental studies and bioinformatic comprehensive efforts have provided reliable and updated compendiums of the human protein interactome. In this work, we present a current view of available databases of human protein–protein interactions (PPIs) that allow building protein interaction networks. We also investigate human proteins as targets of specific drugs to analyze how chemicals interact with different target proteins, placing also the study in a network relational space. Hence, we undertake a description of several major drug–target resources to provide a present perspective of the associations between human proteins and specific chemicals. The identification of molecular targets for specific drugs is a critical step to improve disease therapy. As different diseases have different biomolecular scenarios, we addressed the identification of drug-targeted genes focusing our investigations on cancer and cancer genes. So, a description of resources that provide curated compendiums of human cancer genes is presented. Cancer is a complex disease where multiple genetic ...
Source: Advances in Protein Chemistry and Structural Biology - Category: Biochemistry Source Type: research