Structural and functional studies of differentially O ‐glycosylated analogs of a thrombin inhibitory peptide – variegin

This report, for the first time, describes the impact of differential glycosylation on the function of a thrombin inhibitory peptide and tries to provide structural insights into the relevance of peptide glycosylation in thrombin inhibition. Copyright © 2017 European Peptide Society and John Wiley & Sons, Ltd.

Variegin is a glycoslated peptide isolated from Amblyomma variegatum. The identity of its glycosylation is unknown. Hence, four different glycosylated analogs of variegin were synthesized, and their functional and structural properties were studied.

Source: Journal of Peptide Science - November 7, 2017 Category: Biochemistry Authors: Pidathala R. V. Shabareesh, Ashish Kumar, Dinakar M. Salunke, Kanwal J. Kaur Tags: Research Article Source Type: research