Enhanced TH17 Responses in Patients with IL10 Receptor Deficiency and Infantile-onset IBD

Conclusions: IL10R signaling regulates TH17 polarization and T-cell proliferation in humans but is not required for the generation and in vitro suppression of Tregs. Therapies targeting the TH17 axis might be beneficial for IL10- and IL10R-deficient patients as a bridge to allogeneic hematopoietic stem cell transplantation.
Source: Inflammatory Bowel Diseases - Category: Gastroenterology Tags: Original Basic Science Articles Source Type: research