Diagnostic performance of an optimized transcriptomic signature of risk of tuberculosis in cryopreserved peripheral blood mononuclear cells

A staggering 23% of the global population is estimated to be infected with Mycobacterium tuberculosis (M.tb) [1], representing an enormous reservoir of individuals at risk of progressing to active tuberculosis (TB) disease. Identification of those at risk of TB disease would allow targeted preventive therapy, potentially curtailing transmission [2]. We recently identified and validated a 16-gene whole blood transcriptomic correlate of risk (CoR) signature that can predict active TB disease in M.tb-infected individuals more than a year before disease manifestations and diagnosis [3].

Source: Tuberculosis - November 6, 2017 Category: Respiratory Medicine Authors: Fatoumatta Darboe, Stanley Kimbung Mbandi, Ethan G. Thompson, Michelle Fisher, Miguel Rodo, Michele van Rooyen, Elizabeth Filander, Nicole Bilek, Simbarashe Mabwe, Mark Hatherill, Daniel E. Zak, Adam Penn-Nicholson, Thomas J. Scriba, The SATVI Clinical Im Source Type: research