Association of High Anti ‐Cyclic Citrullinated Peptide Seropositivity and Lean Mass Index with Low Bone Mineral Density in Rheumatoid Arthritis

ConclusionHigh anti‐CCP positivity and ALMI were strongly associated with BMD in patients with RA. The linear relationship of anti‐CCP levels with lower BMD supports the hypothesis that processes specific to RA negatively impact BMD. In contrast, ALMI was positively associated with BMD, emphasizing the importance of this potentially modifiable risk factor. Our findings highlight the complicated interplay of RA disease‐specific and functional factors and their impact on bone mass.This article is protected by copyright. All rights reserved.

Source: Arthritis Care and Research - November 1, 2017 Category: Rheumatology Authors: Katherine D. Wysham, Dolores M. Shoback, John B. Imboden, Patricia P. Katz Tags: Original Article Source Type: research