p120-Catenin Downregulation and PIK3CA Mutations Cooperate to Induce Invasion through MMP1 in HNSCC

In conclusion, this study demonstrates that P120CTN downregulation and PIK3CA mutations promote MMP1-driven invasion, providing a potential novel target for limiting metastasis in HNSCC. Implications: Because of its role in invasion, MMP1 represents a novel, potential target for limiting metastasis in a subset of HNSCCs with P120CTN downregulation and PIK3CA mutations. Mol Cancer Res; 15(10); 1398–409. ©2017 AACR.

http://mcr.aacrjournals.org/cgi/content/short/15/10/1398?rss=1

Source: Molecular Cancer Research - October 1, 2017 Category: Cancer & Oncology Authors: Kidacki, M., Lehman, H. L., Green, M. V., Warrick, J. I., Stairs, D. B. Tags: Oncogenes and Tumor Suppressors Source Type: research