EGFR Mutations Compromise Hypoxia-Associated Radiation Resistance through Impaired Replication Fork-Associated DNA Damage Repair

This study demonstrates that within an altered DNA damage response of hypoxic NSCLC cells, mutant EGFR expression, or EGFR blockade by cetuximab exerts a synthetic lethality effect and significantly compromises radiation resistance in hypoxic tumor cells. Mol Cancer Res; 15(11); 1503–16. ©2017 AACR.

Source: Molecular Cancer Research - October 31, 2017 Category: Cancer & Oncology Authors: Saki, M., Makino, H., Javvadi, P., Tomimatsu, N., Ding, L.-H., Clark, J. E., Gavin, E., Takeda, K., Andrews, J., Saha, D., Story, M. D., Burma, S., Nirodi, C. S. Tags: DNA Damage and Repair Source Type: research