Germline Genetic Variants and Lung Cancer Survival in African Americans

Conclusions: We identified an association between rs1878022 in CMKLR1 and lung cancer survival. However, our results in African Americans have a different direction of effect compared with a prior study in European Americans, suggesting a different genetic architecture or presence of gene–environment interactions. We also identified variants on chromosome 6 within the gene-rich HLA region, which has been previously implicated in lung cancer risk and survival.
Impact: We found evidence that inherited genetic risk factors influence lung cancer survival in African Americans. Replication in additional populations is necessary to confirm potential genetic differences in lung cancer survival across populations. Cancer Epidemiol Biomarkers Prev; 26(8); 1288–95. ©2017 AACR.

Source: Cancer Epidemiology Biomarkers and Prevention - August 1, 2017 Category: Cancer & Oncology Authors: Jones, C. C., Bush, W. S., Crawford, D. C., Wenzlaff, A. S., Schwartz, A. G., Wiencke, J. K., Wrensch, M. R., Blot, W. J., Chanock, S. J., Grogan, E. L., Aldrich, M. C. Tags: Research Articles Source Type: research